Open AccessNormal CD16 Expression and Phagocytosis ofMycobacterium aviumComplex by Monocytes from a Current Cohort of HIV‐1–Infected Patients
Author(s) -
Anthony Jaworowski,
Philip Ellery,
Clare Maslin,
Eman Naim,
Amy Candy Heinlein,
Claire Ryan,
Geza Paukovics,
Jane S. Hocking,
Secondo Sonza,
Suzanne M. Crowe
Publication year - 2006
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/500367
Subject(s) - phagocytosis , cd16 , human immunodeficiency virus (hiv) , immunology , cohort , mycobacterium avium complex , nontuberculous mycobacteria , microbiology and biotechnology , monocyte , macrophage , virology , medicine , biology , mycobacterium , immune system , tuberculosis , pathology , in vitro , genetics , cd3 , cd8
Monocyte phenotype and function were measured in whole blood sampled from a current cohort of human immunodeficiency virus (HIV)-infected individuals attending a large, metropolitan, university-affiliated hospital. There was no significant difference in the prevalence of CD16+ monocytes or the capacity of monocytes to ingest heat-killed Mycobacterium avium complex between these individuals and HIV-uninfected control subjects, regardless of viral load, current CD4+ T cell count, nadir CD4+ T cell count, or time since diagnosis of HIV infection. CD16+ monocyte prevalence was, however, elevated in patients not currently receiving antiretroviral therapy. We conclude that HIV type 1 infection in the setting of highly active antiretroviral therapy is associated with normal monocyte function and phenotype.
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