Persistent Neuroinvasive West Nile Virus Infection in an Immunocompromised Patient | Zendy

Robert G. Penn | Zendy; Jeannette Guarner | Zendy; James J. Sejvar | Zendy; Hassan Hartman | Zendy; Rodney D. McComb | Zendy; Diana L. Nevins | Zendy; Julu Bhatnagar | Zendy; Sherif R. Zaki | Zendy

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Persistent Neuroinvasive West Nile Virus Infection in an Immunocompromised Patient

Author(s) -

Robert G. Penn,

Jeannette Guarner,

James J. Sejvar,

Hassan Hartman,

Rodney D. McComb,

Diana L. Nevins,

Julu Bhatnagar,

Sherif R. Zaki

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/500216

Subject(s) - medicine , west nile virus , meningoencephalitis , virology , autopsy , virus , antibody , lymphoma , pathogenesis , immunology , pathology

A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

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