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After continuous exposure to malarial infections in regions of Africa where malaria is hyperendemic, children attain clinical immunity. This immunity results, in part, from the acquisition of antibodies against a large repertoire of variant antigens expressed on the surface of infected erythrocytes, such as the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). We determined whether a subunit vaccine to a portion of PfEMP1 could induce protection in nonhuman primates.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Immunization of<i>Aotus</i>Monkeys with Recombinant Cysteine‐Rich Interdomain Region 1α Protects against Severe Disease during<i>Plasmodium falciparum</i>Reinfection

Immunization ofAotusMonkeys with Recombinant Cysteine‐Rich Interdomain Region 1α Protects against Severe Disease duringPlasmodium falciparumReinfection