Dynamics of Anti‐VAR2CSA Immunoglobulin G Response in a Cohort of Senegalese Pregnant Women | Zendy

Nicaise Tuikue Ndam | Zendy; Ali Salanti | Zendy; JeanYves Le Hesran | Zendy; Gilles Cottrell | Zendy; Nadine Fiévet | Zendy; Louise Turner | Zendy; Sokhna Sow | Zendy; Jean-Marie Dangou | Zendy; Thor G. Theander | Zendy; Philippe Deloron | Zendy

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Dynamics of Anti‐VAR2CSA Immunoglobulin G Response in a Cohort of Senegalese Pregnant Women

Author(s) -

Nicaise Tuikue Ndam,

Ali Salanti,

JeanYves Le Hesran,

Gilles Cottrell,

Nadine Fiévet,

Louise Turner,

Sokhna Sow,

Jean-Marie Dangou,

Thor G. Theander,

Philippe Deloron

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/500146

Subject(s) - cohort , antibody , medicine , immunoglobulin g , pregnancy , immunoglobulin m , immunology , cohort study , biology , genetics

Pregnancy-associated malaria (PAM) is precipitated by the accumulation of parasites in the placental intervillous spaces and causes maternal anemia and low birth weight. In PAM, placental parasites adhere to chondroitin sulfate A (CSA) through a unique set of variant surface antigens (VSAPAM). Several studies have shown that 1 var gene, var2csa, is transcribed at high levels and expressed in CSA-binding Plasmodium falciparum parasites.

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