A Tale of Two -Herpesviruses: Lessons for Vaccinologists | Zendy

Barry T. Rouse | Zendy; Shilpa Deshpande Kaistha | Zendy

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A Tale of Two -Herpesviruses: Lessons for Vaccinologists

Author(s) -

Barry T. Rouse,

Shilpa Deshpande Kaistha

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/500141

Subject(s) - virology , varicella zoster virus , herpes simplex virus , virus , medicine , herpesviridae , varicella vaccine , alphaherpesvirinae , immunology , viral disease , immunization , immune system

Of the 8 known herpesviruses that affect human beings, we only have successful vaccines against varicella zoster virus. This brief review compares the pathogenesis of varicella zoster virus with that of the closely related alpha-herpesviruses herpes simplex virus 1 and 2, for which we have no satisfactory vaccines. The main objective of this review is to learn lessons from the success of varicella zoster virus vaccine that could be exploited for the development of successful vaccines against herpes simplex virus and perhaps against other herpes viruses.

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