Real-Time Polymerase Chain Reaction Assay for the Rapid Detection and Characterization of Chloroquine-Resistant Plasmodium falciparum Malaria in Returned Travelers | Zendy

Gabriella A. Farcas | Zendy; Rainer Soeller | Zendy; Kai Zhong | Zendy; Alireza Zahirieh | Zendy; Kevin C. Kain | Zendy

Open Access

Real-Time Polymerase Chain Reaction Assay for the Rapid Detection and Characterization of Chloroquine-Resistant Plasmodium falciparum Malaria in Returned Travelers

Author(s) -

Gabriella A. Farcas,

Rainer Soeller,

Kai Zhong,

Alireza Zahirieh,

Kevin C. Kain

Publication year - 2006

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/500134

Subject(s) - malaria , plasmodium falciparum , virology , plasmodium malariae , chloroquine , polymerase chain reaction , plasmodium vivax , nested polymerase chain reaction , biology , drug resistance , plasmodium ovale , restriction fragment length polymorphism , medicine , immunology , microbiology and biotechnology , genetics , gene

Imported drug-resistant malaria is a growing problem in industrialized countries. Rapid and accurate diagnosis is essential to prevent malaria-associated mortality in returned travelers. However, outside of a limited number of specialized centers, the microscopic diagnosis of malaria is slow, unreliable, and provides little information about drug resistance. Molecular diagnostics have the potential to overcome these limitations.

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