Expression of Programmed Death–1 Ligand (PD‐L) 1, PD‐L2, B7‐H3, and Inducible Costimulator Ligand on Human Respiratory Tract Epithelial Cells and Regulation by Respiratory Syncytial Virus and Type 1 and 2 Cytokines | Zendy

L Stanciu | Zendy; Cinzia Maria Bellettato | Zendy; Vasile LazaStanca | Zendy; Anthony J. Coyle | Zendy; Alberto Papi | Zendy; Sebastian L. Johnston | Zendy

Open Access

Expression of Programmed Death–1 Ligand (PD‐L) 1, PD‐L2, B7‐H3, and Inducible Costimulator Ligand on Human Respiratory Tract Epithelial Cells and Regulation by Respiratory Syncytial Virus and Type 1 and 2 Cytokines

Author(s) -

L Stanciu,

Cinzia Maria Bellettato,

Vasile LazaStanca,

Anthony J. Coyle,

Alberto Papi,

Sebastian L. Johnston

Publication year - 2006

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/499275

Subject(s) - respiratory tract , immune system , pd l1 , respiratory system , biology , interferon , immunology , interferon gamma , immunotherapy , anatomy

Respiratory syncytial virus (RSV) is associated with wheezing illness, and infections can occur repeatedly throughout life. We hypothesized that RSV infection of respiratory tract epithelial cells up-regulates B7 molecules that regulate memory immune responses and that type 1 and 2 cytokines differentially modulate this induction.

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