Group A Streptococcus (GAS) Carbohydrate as an Immunogen for Protection against GAS Infection | Zendy

Hemant Sabharwal | Zendy; Francis Michon | Zendy; Daniel Nelson | Zendy; Wenling Dong | Zendy; Kathleen Fuchs | Zendy; Roberto Carreño Manjarrez | Zendy; Arun K. Sarkar | Zendy; Catherine Uitz | Zendy; Ann ViteriJackson | Zendy; Romeo S. Rodriguez Suarez | Zendy; Milan S. Blake | Zendy; John B. Zabriskie | Zendy

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Group A Streptococcus (GAS) Carbohydrate as an Immunogen for Protection against GAS Infection

Author(s) -

Hemant Sabharwal,

Francis Michon,

Daniel Nelson,

Wenling Dong,

Kathleen Fuchs,

Roberto Carreño Manjarrez,

Arun K. Sarkar,

Catherine Uitz,

Ann ViteriJackson,

Romeo S. Rodriguez Suarez,

Milan S. Blake,

John B. Zabriskie

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/498618

Subject(s) - immunogen , streptococcus pyogenes , toxoid , antibody , microbiology and biotechnology , streptococcus , streptococcus pneumoniae , group a , serotype , biology , immunology , chemistry , medicine , immunization , monoclonal antibody , bacteria , antibiotics , staphylococcus aureus , genetics

Previous studies have shown that human serum containing anti-group A streptococcus carbohydrate (GAS CHO) antibodies were opsonic for different M protein-carrying serotypes. To investigate the role that anti-GAS CHO antibodies play in passive and active protection, mice were immunized subcutaneously or intranasally with GAS CHO conjugated to tetanus toxoid, and mortality and oral colonization were monitored after challenge with live GAS. Compared with control mice, immunized mice were significantly protected against systemic or nasal challenge with GAS. Furthermore, studies of serum samples and throat cultures from Mexican children revealed an inverse relationship between high serum titers of anti-GAS CHO antibodies and the presence of GAS in the throat. Anti-GAS CHO antibodies were also tested for cross-reactivity with human tissues and cytoskeletal proteins. No cross-reactivity was observed in either assay. The present study demonstrates that GAS CHO is both immunogenic and protective against GAS infections.

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