Chlamydia pneumoniaeAlters Mildly Oxidized Low‐Density Lipoprotein–Induced Cell Death in Human Endothelial Cells, Leading to Necrosis Rather Than Apoptosis | Zendy

Dani Nazzal | Zendy; AnneValérie Cantéro | Zendy; Nicole Therville | Zendy; Bruno Ségui | Zendy; Anne NègreSalvayre | Zendy; Mogens Thomsen | Zendy; Hervé Benoist | Zendy

Open Access

Chlamydia pneumoniaeAlters Mildly Oxidized Low‐Density Lipoprotein–Induced Cell Death in Human Endothelial Cells, Leading to Necrosis Rather Than Apoptosis

Author(s) -

Dani Nazzal,

AnneValérie Cantéro,

Nicole Therville,

Bruno Ségui,

Anne NègreSalvayre,

Mogens Thomsen,

Hervé Benoist

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/498617

Subject(s) - apoptosis , programmed cell death , fragmentation (computing) , biology , dna fragmentation , necrosis , reactive oxygen species , cytochrome c , oxidative stress , poly adp ribose polymerase , microbiology and biotechnology , biochemistry , polymerase , dna , ecology , genetics

Atherosclerosis is characterized by oxidative stress that induces lipid and protein oxidation in the vascular wall. Oxidized low-density lipoproteins (oxLDLs) are present in lesions, and one of their actions is to induce apoptosis or necrosis in vascular cells. A role for Chlamydia pneumoniae in atherosclerosis has been proposed, but the mechanisms involved remain largely unknown.

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