Open AccessDistribution and Clinical Impact of Human Respiratory Syncytial Virus Genotypes in Hospitalized Children over 2 Winter Seasons
Author(s) -
Rodica Gilca,
Gaston De Serres,
Mireille Tremblay,
MarieLouise C. Vachon,
Éric Leblanc,
Michel G. Bergeron,
Pierre Déry,
Guy Boivin
Publication year - 2005
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/498526
Subject(s) - genotype , virus , intensive care unit , respiratory system , biology , virology , polymerase chain reaction , respiratory disease , reverse transcription polymerase chain reaction , disease , pneumovirus , intensive care , medicine , paramyxoviridae , gene , immunology , viral disease , gene expression , intensive care medicine , genetics , lung
Sequencing studies of the glycoprotein G gene were performed in human respiratory syncytial virus (hRSV) strains detected by reverse-transcription polymerase chain reaction directly from nasopharyngeal aspirates of hospitalized children < or =3 years old over 2 winters. Clinical data were compared between 106 children infected with group A hRSV (96 GA2 genotypes) and 94 children infected with hRSV group B (62 GB3 genotypes). A severity index was defined by assigning 1 point each for the use of >30% supplemental oxygen, admission to an intensive-care unit, and duration of hospital stay of >5 days. Group A and genotype GA2 strains were associated with greater severity of hRSV disease than were group B strains.
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