Dihydropteroate Synthase Mutations in the folP1 Gene Predict Dapsone Resistance in Relapsed Cases of Leprosy | Zendy

Emmanuelle Cambau | Zendy; Laëtitia Carthagéna | Zendy; Aurélie Chauffour | Zendy; Botao Ji | Zendy; Vincent Jarlier | Zendy

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Dihydropteroate Synthase Mutations in the folP1 Gene Predict Dapsone Resistance in Relapsed Cases of Leprosy

Author(s) -

Emmanuelle Cambau,

Laëtitia Carthagéna,

Aurélie Chauffour,

Botao Ji,

Vincent Jarlier

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/498506

Subject(s) - dapsone , dihydropteroate synthase , mycobacterium leprae , leprosy , microbiology and biotechnology , mutation , medicine , gene , virology , biology , genetics , immunology , malaria , pyrimethamine , chloroquine

Molecular detection was compared with the mouse footpad inoculation test for detection of dapsone resistance in 38 strains of Mycobacterium leprae. Mutations of the folP1 gene (at codons 53 or 55) were found in 6 of 6 strains with high-level resistance, in 3 of 4 strains with intermediate-level resistance, and in 1 of 6 strains with low-level resistance, but not in 22 dapsone-susceptible strains. In cases of infection with strains of M. leprae carrying the folP1 mutation, therapy with dapsone may be replaced by therapy with a fluoroquinolone.

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