Efficacy of Cerebrospinal Fluid (CSF)–Penetrating Antiretroviral Drugs against HIV in the Neurological Compartment: Different Patterns of Phenotypic Resistance in CSF and Plasma
Author(s) -
Andrea Antinori,
Carlo Federico Perno,
Maria Letizia Giancola,
Federica Forbici,
Giuseppe Ippolito,
Richard M. W. Hoetelmans,
Stephen C. Piscitelli
Publication year - 2005
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/498310
Subject(s) - cerebrospinal fluid , medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , phenotype , immunology , compartment (ship) , population , lentivirus , virus , viral disease , virology , pathology , viral load , biology , biochemistry , oceanography , environmental health , gene , geology
Cerebrospinal fluid (CSF) concentrations of multiple drugs in a large human immunodeficiency virus (HIV)-infected patient population, the virtual phenotype profiles for HIV in the plasma and CSF compartments, and the correlation of these profiles with exposure to antiretroviral therapy need to be further investigated.
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