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3. Barza M, Ioannidis JP, Cappelleri JC, Lau J. Single or multiple daily doses of aminoglycosides: a meta-analysis. BMJ 1996; 312:338–45. 4. Leibovici L, Paul M, Poznanski O, et al. Monotherapy versus beta-lactam–aminoglycoside combination treatment for Gram-negative bacteremia: a prospective, observational study. Antimicrob Agents Chemother 1997; 41:1127–33. 5. Falagas ME. Monotherapy versus beta-lactam–aminoglycoside combination therapy for gram-negative bacteremia. Antimicrob Agents Chemother 1997; 41:2593–4. 6. Safdar N, Handelsman J, Maki DG. Does combination antimicrobial therapy reduce mortality in gram-negative bacteraemia: a meta-analysis. Lancet Infect Dis 2004; 4:519–27.

Failure of Primaquine Therapy for the Treatment of Plasmodium ovale Malaria