Reduced-Dose Intradermal Vaccination against Hepatitis A with an Aluminum-Free Vaccine Is Immunogenic and Can Lower Costs | Zendy

Chitsanu Pancharoen | Zendy; Jutarat Mekmullica | Zendy; Usa Thisyakorn | Zendy; Songsri Kasempimolporn | Zendy; Henry Wilde | Zendy; Christian Herzog | Zendy

Open Access

Reduced-Dose Intradermal Vaccination against Hepatitis A with an Aluminum-Free Vaccine Is Immunogenic and Can Lower Costs

Author(s) -

Chitsanu Pancharoen,

Jutarat Mekmullica,

Usa Thisyakorn,

Songsri Kasempimolporn,

Henry Wilde,

Christian Herzog

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/497266

Subject(s) - medicine , hepatitis a vaccine , vaccination , titer , virology , hepatitis a , booster dose , immunology , booster (rocketry) , virus , hepatitis , physics , astronomy

A reduced dose (0.1 mL) of intradermal hepatitis A virus (HAV) vaccine could facilitate the control of hepatitis A in countries of endemicity. All study subjects receiving an aluminum-free HAV vaccine intradermally were seroprotected 28 days after vaccination (anti-HAV titer, > or =10 mIU/mL). Seroprotection rates decreased to 80.8% at 12 months but returned to 100%, with titers increasing 28-fold, after receipt of a booster vaccination.

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