Open AccessConjugate Pneumococcal Vaccine in HIV‐Infected Ugandans and the Effect of Past Receipt of Polysaccharide Vaccine
Author(s) -
George Miiro,
Helena Käyhty,
Christine Watera,
Helen Tolmie,
James Whitworth,
Charles F. Gilks,
Neil French
Publication year - 2005
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/497144
Subject(s) - immunogenicity , pneumococcal conjugate vaccine , serotype , virology , pneumococcal polysaccharide vaccine , pneumococcal vaccine , immunology , medicine , pneumococcal infections , streptococcus pneumoniae , antibody , biology , microbiology and biotechnology , antibiotics , pneumococcal disease
We investigated the immunogenicity of a 7-valent conjugate pneumococcal vaccine (CPV) in human immunodeficiency virus-infected Ugandan adults and measured the effect of past pneumococcal polysaccharide vaccine (PPV) receipt given as part of a controlled trial. Two doses of CPV, 4 weeks apart, were given to 54 past PPV recipients and 55 past placebo recipients (84% female; median CD4 cell count, 251 cells/ microL [range, 1-936 cells/ microL]). Postvaccination anticapsular immunoglobulin G (IgG) concentrations were directly correlated with CD4 cell count (P < .01 for all serotypes). There were significant increases in anticapsular IgG concentrations for all serotypes after the first dose (P < .01) and for all serotypes except 14 and 9V after the second dose. Past receipt of PPV did not affect vaccine response.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom