Open AccessClinical Significance of In Vitro Replication–Enhancing Mutations of the Hepatitis C Virus (HCV) Replicon in Patients with Chronic HCV Infection
Author(s) -
Christoph Sarrazin,
Ulrike Mihm,
Eva Herrmann,
Christoph Welsch,
Mario Albrecht,
Ulrike Sarrazin,
Stella Traver,
Thomas Lengauer,
Stefan Zeuzem
Publication year - 2005
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/497142
Subject(s) - ns5a , ns5b , replicon , ns3 , virology , hepatitis c virus , biology , viral replication , rna , virus , hepacivirus , flaviviridae , gene , genetics , plasmid
Mutations in nonstructural (NS) hepatitis C virus (HCV) proteins enhance replication in HCV-1a/b replicons. The prevalence of such mutations and their clinical significance in vivo are unknown.
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