Strategy of Following Voriconazole versus Amphotericin B Therapy with Other Licensed Antifungal Therapy for Primary Treatment of Invasive Aspergillosis: Impact of Other Therapies on Outcome
Author(s) -
Thomas F. Patterson,
Helen W. Boucher,
Raoul Herbrecht,
David W. Denning,
Olivier Lortholary,
Patricia Ribaud,
R H Rubin,
John R. Wingard,
Ben E. dePauw,
Haran T. Schlamm,
Peter F. Troke,
John E. Bennett
Publication year - 2005
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/497126
Subject(s) - voriconazole , amphotericin b deoxycholate , amphotericin b , medicine , aspergillosis , randomized controlled trial , mycosis , gastroenterology , surgery , antifungal , caspofungin , immunology , dermatology
In a previous randomized trial of voriconazole versus amphotericin B deoxycholate for primary therapy of invasive aspergillosis, voriconazole demonstrated superior efficacy and better survival. In that trial, treatment with voriconazole or amphotericin B deoxycholate could be followed with other licensed antifungal therapies (OLAT). Here, we report the impact of OLAT on the outcome of patients with invasive aspergillosis.
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