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We investigated the minimum inhibitory concentrations of some fluoroquinolones for Mycoplasma genitalium and their bacteriological efficacy in the treatment of M. genitalium-positive nongonococcal urethritis. In vitro, levofloxacin was less active than gatifloxacin, tosufloxacin, and sparfloxacin. In vivo, the bacteriological efficacy of gatifloxacin was superior to that of levofloxacin or tosufloxacin.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

In Vitro Activity of Fluoroquinolones against Mycoplasma genitalium and Their Bacteriological Efficacy for Treatment of M. genitalium-Positive Nongonococcal Urethritis in Men