Whipple Disease: Intestinal Infiltrating Cells Exhibit a Transcriptional Pattern of M2/Alternatively Activated Macrophages | Zendy

Benoît Desnues | Zendy; Hubert Lépidi | Zendy; Didier Raoult | Zendy; JeanLouis Mège | Zendy

Open Access

Whipple Disease: Intestinal Infiltrating Cells Exhibit a Transcriptional Pattern of M2/Alternatively Activated Macrophages

Author(s) -

Benoît Desnues,

Hubert Lépidi,

Didier Raoult,

JeanLouis Mège

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/491745

Subject(s) - tropheryma whipplei , lamina propria , whipple's disease , biology , periodic acid–schiff stain , pathology , whipple disease , pathophysiology , gene expression , microbiology and biotechnology , gene , disease , immunology , immunohistochemistry , medicine , epithelium , biochemistry , coeliac disease , intestinal malabsorption

Whipple disease (WD) is a rare systemic disease caused by Tropheryma whipplei and is characterized by the presence of foamy macrophages with periodic acid-Schiff-positive inclusions in tissues such as lamina propria. For the first time, we report the gene-expression profile of macrophages in intestinal lesions from a patient with WD. Microarray and real-time polymerase chain reaction revealed that genes encoding CCL18, cathepsins, scavenger receptor, interleukin-10, and lipid metabolites were up-regulated in intestinal lesions. This transcriptional pattern corresponds to that of M2/alternatively activated macrophages. Our results suggest that the T helper 2 response in the intestinal environment may account for the pathophysiological properties of WD.

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