A Recessive Major Gene Controls the Mitsuda Reaction in a Region Endemic for Leprosy | Zendy

Brigitte Ranque | Zendy; Alexandre Alcaïs | Zendy; Nguyen Van Thuc | Zendy; Sébastien Woynard | Zendy; Vu Hong Thai | Zendy; Nguyễn Thu Hương | Zendy; Nguyen Ngoc Ba | Zendy; Pham Xuan Khoa | Zendy; Erwin Schurr | Zendy; Laurent Abel | Zendy

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A Recessive Major Gene Controls the Mitsuda Reaction in a Region Endemic for Leprosy

Author(s) -

Brigitte Ranque,

Alexandre Alcaïs,

Nguyen Van Thuc,

Sébastien Woynard,

Vu Hong Thai,

Nguyễn Thu Hương,

Nguyen Ngoc Ba,

Pham Xuan Khoa,

Erwin Schurr,

Laurent Abel

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/466535

Subject(s) - leprosy , mycobacterium leprae , allele , genetic linkage , gene , immunology , biology , genetics , medicine

Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The Mitsuda reaction is a delayed granulomatous skin reaction elicited by intradermal injection of heat-killed M. leprae. Interestingly, results of the Mitsuda test are positive in the majority of individuals, even in areas not endemic for M. leprae. Like leprosy, the Mitsuda reaction is thought to be genetically controlled, but its mode of inheritance is unknown, although the role of the NRAMP1 gene has previously been reported.

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