A Longitudinal Molecular Surveillance Study of Human Polyomavirus Viremia in Heart, Kidney, Liver, and Pancreas Transplant Patients | Zendy

Raymund R. Razonable | Zendy; Robert A. Brown | Zendy; Atul Humar | Zendy; Emma Covington | Zendy; Emma Alecock | Zendy; Carlos V. Payá | Zendy

Open Access

A Longitudinal Molecular Surveillance Study of Human Polyomavirus Viremia in Heart, Kidney, Liver, and Pancreas Transplant Patients

Author(s) -

Raymund R. Razonable,

Robert A. Brown,

Atul Humar,

Emma Covington,

Emma Alecock,

Carlos V. Payá

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/466532

Subject(s) - subclinical infection , viremia , medicine , pancreas , kidney , jc virus , pancreas transplantation , polyomavirus infections , pathology , heart transplantation , bk virus , kidney transplantation , transplantation , gastroenterology , virology , immunology , virus , progressive multifocal leukoencephalopathy

In this study of 263 heart, kidney, liver, and pancreas transplant patients, BK virus (BKV) and JC virus (JCV) DNAemia were observed most commonly in kidney and/or pancreas transplant patients (26%), although they were also observed, to a lesser extent, in heart (7%) and liver (4%) transplant patients. The majority of episodes of polyomavirus DNAemia were subclinical, although, in some cases, BKV DNAemia was associated with kidney rejection, and JCV DNAemia was accompanied by nonspecific symptoms. Hence, BKV and JCV DNAemia are not uncommon during the first year after kidney, heart, liver, and pancreas transplantation, and they could be associated with certain clinical syndromes in transplant patients.

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