Two Randomized Controlled Trials of Ceftazidime Alone versus Ceftazidime in Combination with Trimethoprim-Sulfamethoxazole for the Treatment of Severe Melioidosis | Zendy

Wirongrong Chierakul | Zendy; Siriluck Anunnatsiri | Zendy; John M. Short | Zendy; Bina Maharjan | Zendy; Piroon Mootsikapun | Zendy; Andrew J. H. Simpson | Zendy; Direk Limmathurotsakul | Zendy; Allen C. Cheng | Zendy; Kasia Stepniewska | Zendy; Paul N. Newton | Zendy; Wipada Chaowagul | Zendy; Nicholas J. White | Zendy; Sharon J. Peacock | Zendy; N. P. Day | Zendy; P. Chetchotisakd | Zendy

Open Access

Two Randomized Controlled Trials of Ceftazidime Alone versus Ceftazidime in Combination with Trimethoprim-Sulfamethoxazole for the Treatment of Severe Melioidosis

Author(s) -

Wirongrong Chierakul,

Siriluck Anunnatsiri,

John M. Short,

Bina Maharjan,

Piroon Mootsikapun,

Andrew J. H. Simpson,

Direk Limmathurotsakul,

Allen C. Cheng,

Kasia Stepniewska,

Paul N. Newton,

Wipada Chaowagul,

Nicholas J. White,

Sharon J. Peacock,

N. P. Day,

P. Chetchotisakd

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/444456

Subject(s) - melioidosis , ceftazidime , medicine , burkholderia pseudomallei , sulfamethoxazole , trimethoprim , randomized controlled trial , ceftazidime/avibactam , intensive care medicine , antibiotics , microbiology and biotechnology , bacteria , pseudomonas aeruginosa , pathology , biology , genetics

Two antibiotic regimens are used commonly in Thailand for the initial treatment of severe melioidosis: ceftazidime in combination with trimethoprim-sulfamethoxazole (TMP-SMX) and ceftazidime monotherapy. It is not known whether TMP-SMX provides an additional benefit.

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