Associations betweenStaphylococcus aureusGenotype, Infection, and In‐Hospital Mortality: A Nested Case‐Control Study | Zendy

Heiman Wertheim | Zendy; Willem B. van Leeuwen | Zendy; Susan V. Snijders | Zendy; Martine De Vos | Zendy; Andreas Voß | Zendy; Christina M. J. E. VandenbrouckeGrauls | Zendy; Jan Kluytmans | Zendy; Henri A. Verbrugh | Zendy; Alex van Belkum | Zendy

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Associations betweenStaphylococcus aureusGenotype, Infection, and In‐Hospital Mortality: A Nested Case‐Control Study

Author(s) -

Heiman Wertheim,

Willem B. van Leeuwen,

Susan V. Snijders,

Martine De Vos,

Andreas Voß,

Christina M. J. E. VandenbrouckeGrauls,

Jan Kluytmans,

Henri A. Verbrugh,

Alex van Belkum

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/444427

Subject(s) - staphylococcus aureus , multilocus sequence typing , carriage , asymptomatic carrier , genotype , odds ratio , virulence , staphylococcal infections , medicine , anterior nares , microbiology and biotechnology , typing , confidence interval , methicillin resistant staphylococcus aureus , biology , virology , asymptomatic , bacteria , pathology , genetics , gene

We screened 14,008 adult nonsurgical patients for Staphylococcus aureus nasal carriage at hospital admission and assessed them for invasive S. aureus disease and in-hospital mortality. Multilocus sequence typing was performed on endogenous invasive strains and nasal strains of matched asymptomatic carriers to investigate whether virulent clones could be identified in nasal carriers. Clonal complex (CC) 45 was significantly underrepresented (odds ratio [OR], 0.16 [95% confidence interval {CI}, 0.04-0.59]) and CC30 was overrepresented (not statistically significant) among invasive strains (OR, 1.91 [95% CI, 0.91-4.0]). The distribution of CCs of invasive S. aureus strains in noncarriers did not differ from that in carriers. Those infected with S. aureus strains belonging to a CC had higher mortality than those infected with strains not belonging to a CC (P<.05), which indicates the coevolution of S. aureus virulence and spread in humans.

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