Non–Travel‐Associated Hepatitis E in England and Wales: Demographic, Clinical, and Molecular Epidemiological Characteristics | Zendy

Samreen Ijaz | Zendy; Eve Arnold | Zendy; M. Banks | Zendy; Richard Bendall | Zendy; Matthew Cramp | Zendy; Richard Cunningham | Zendy; Harry R. Dalton | Zendy; Tim J. Harrison | Zendy; Simon Hill | Zendy; Lorna Macfarlane | Zendy; R. Meigh | Zendy; Shuja Shafi | Zendy; Martin J. Sheppard | Zendy; Jacquie Smithson | Zendy; Melanie P. Wilson | Zendy; ChongGee Teo | Zendy

Open Access

Non–Travel‐Associated Hepatitis E in England and Wales: Demographic, Clinical, and Molecular Epidemiological Characteristics

Author(s) -

Samreen Ijaz,

Eve Arnold,

M. Banks,

Richard Bendall,

Matthew Cramp,

Richard Cunningham,

Harry R. Dalton,

Tim J. Harrison,

Simon Hill,

Lorna Macfarlane,

R. Meigh,

Shuja Shafi,

Martin J. Sheppard,

Jacquie Smithson,

Melanie P. Wilson,

ChongGee Teo

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/444396

Subject(s) - hepatitis e virus , epidemiology , genotype , fulminant hepatitis , viral hepatitis , medicine , hepatitis a , demography , molecular epidemiology , hepatitis , disease , hepatitis e , virology , biology , biochemistry , sociology , gene

Between 1996 and 2003, 186 cases of hepatitis E were serologically diagnosed. Of these, 17 (9%) were not associated with recent travel abroad. Patients were >55 years old (range, 56-82 years old) and tended to be male (76%). Two patients presented with fulminant hepatitis. A total of 129 (69%) cases were associated with recent travel to countries where hepatitis E virus (HEV) is hyperendemic. Compared with patients with travel-associated disease, patients with non-travel-associated disease were more likely to be older, living in coastal or estuarine areas, not of South Asian ethnicity, and infected by genotype 3 strains of HEV. The genotype 3 subgenomic nucleotide sequences were unique and closely related to those from British pigs. Patients infected by HEV indigenous to England and Wales tended to belong to a distinct demographic group, there were multiple sources of infection, and pigs might have been a viral reservoir.

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