Human Metapneumovirus Infection Plays an Etiologic Role in Acute Asthma Exacerbations Requiring Hospitalization in Adults | Zendy

John V. Williams | Zendy; James E. Crowe | Zendy; Rachel Enriquez | Zendy; Patricia A. Minton | Zendy; R. Stokes Peebles | Zendy; Robert G. Hamilton | Zendy; Stanley B. Higgins | Zendy; Marie R. Griffin | Zendy; Tina V. Hartert | Zendy

Open Access

Human Metapneumovirus Infection Plays an Etiologic Role in Acute Asthma Exacerbations Requiring Hospitalization in Adults

Author(s) -

John V. Williams,

James E. Crowe,

Rachel Enriquez,

Patricia A. Minton,

R. Stokes Peebles,

Robert G. Hamilton,

Stanley B. Higgins,

Marie R. Griffin,

Tina V. Hartert

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/444392

Subject(s) - human metapneumovirus , medicine , asthma , odds ratio , exacerbation , confidence interval , metapneumovirus , immunology , respiratory tract infections , respiratory system

We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P=.03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.

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