High‐Dose Recombinant Canarypox Vaccine Expressing HIV‐1 Protein, in Seronegative Human Subjects | Zendy

Paul Goepfert | Zendy; Helen Horton | Zendy; M. Juliana McElrath | Zendy; Sanjay Gurunathan | Zendy; Guido Ferrari | Zendy; Georgia D. Tomaras | Zendy; David C. Montefiori | Zendy; Mary Allen | Zendy; YaLin Chiu | Zendy; Paul Spearman | Zendy; Jonathan D. Fuchs | Zendy; Beryl A. Koblin | Zendy; William A. Blattner | Zendy; Sharon E. Frey | Zendy; Michael C. Keefer | Zendy; Lindsey R. Baden | Zendy; Lawrence Corey | Zendy

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High‐Dose Recombinant Canarypox Vaccine Expressing HIV‐1 Protein, in Seronegative Human Subjects

Author(s) -

Paul Goepfert,

Helen Horton,

M. Juliana McElrath,

Sanjay Gurunathan,

Guido Ferrari,

Georgia D. Tomaras,

David C. Montefiori,

Mary Allen,

YaLin Chiu,

Paul Spearman,

Jonathan D. Fuchs,

Beryl A. Koblin,

William A. Blattner,

Sharon E. Frey,

Michael C. Keefer,

Lindsey R. Baden,

Lawrence Corey

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/432915

Subject(s) - reactogenicity , ctl* , medicine , elispot , immunology , hiv vaccine , virology , vaccination , lentivirus , clinical trial , cytotoxic t cell , vaccine trial , human immunodeficiency virus (hiv) , antibody , viral disease , cd8 , immunogenicity , biology , immune system , in vitro , biochemistry

In clinical trials, canarypox ALVAC-human immunodeficiency virus (HIV) vaccines have been shown to elicit human HIV-specific cytotoxic T lymphocyte (CTL) responses in some but not all healthy uninfected adults.Methods. A clinical trial was conducted to examine whether the vaccine vCP1452 would elicit a greater HIV-specific CTL response when given at a dose of 10(8.0) TCID50 (60 participants) than when given at the regular dose, 10(7.26) TCID50 (40 participants); as a control, a placebo vaccine preparation also was administered (10 participants).

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