A Soluble Receptor Decoy Protects Rats against Anthrax Lethal Toxin Challenge | Zendy

Heather M. Scobie | Zendy; Diane Thomas | Zendy; John Marlett | Zendy; Giuseppe Destito | Zendy; Darran J. Wigelsworth | Zendy; R. John Collier | Zendy; John A. T. Young | Zendy; Marianne Manchester | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A Soluble Receptor Decoy Protects Rats against Anthrax Lethal Toxin Challenge

Author(s) -

Heather M. Scobie,

Diane Thomas,

John Marlett,

Giuseppe Destito,

Darran J. Wigelsworth,

R. John Collier,

John A. T. Young,

Marianne Manchester

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/432731

Subject(s) - anthrax toxin , toxin , decoy , antitoxin , bacillus anthracis , microbiology and biotechnology , receptor , neutralization , biology , chemistry , immunology , fusion protein , bacteria , antibody , biochemistry , recombinant dna , genetics , gene

Successful postexposure treatment for inhalation anthrax is thought to include neutralization of anthrax toxin. The soluble anthrax toxin receptor/tumor endothelial marker 8 and capillary morphogenesis protein 2 (sATR/TEM8 and sCMG2, respectively) receptor decoys bind to anthrax toxin protective antigen (PA) and compete with cellular receptors for binding. Here, we show that, in a tissue-culture model of intoxication, sCMG2 is a 11.4-fold more potent antitoxin than sATR/TEM8 and that this increased activity corresponds to an approximately 1000-fold higher PA-binding affinity. Stoichiometric concentrations of sCMG2 protect rats against lethal toxin challenge, making sCMG2 one of the most effective anthrax antitoxins described to date.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research