Moxifloxacin Is Efficacious for Treatment of Community-Acquired Lung Abscesses in Adults

grounds for exclusion of those studies” [8, section 6.10]. Our 11 criteria were determined under the assumption that failure to meet just 1 criterion could potentially invalidate an entire study. The Cochrane Handbook continues with the statement that “if reviewers raise the methodological cut-point for including studies, there will be less variation in validity among the included reports” [8, section 6.10]. Metaanalysis was not attempted in our review, because only 2 studies were deemed experimentally sound. With regard to vitamin C, the purpose of our study was not to review vitamin C studies and their validity. The studies of Diehl [9], Hayden et al. [10], and Chalmers [11] were cited in our review [3] to show the importance of proof of blinding and to demonstrate the placebo effect in action. The importance of proof of blinding has been established as a vital component of experimental design. The Cochrane Handbook states “there is empirical evidence suggesting that...lack of double blinding results in overestimates of the effects of treatment” [8, section 6.11]. We stand by the results reported in our review.