Coculture of THP‐1 Human Mononuclear Cells withCandida albicansResults in Pronounced Changes in Host Gene Expression | Zendy

Katherine S. Barker | Zendy; Teresa Liu | Zendy; P. David Rogers | Zendy

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Coculture of THP‐1 Human Mononuclear Cells withCandida albicansResults in Pronounced Changes in Host Gene Expression

Author(s) -

Katherine S. Barker,

Teresa Liu,

P. David Rogers

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/432487

Subject(s) - thp1 cell line , candida albicans , peripheral blood mononuclear cell , gene expression , biology , microbiology and biotechnology , host (biology) , gene , cell culture , genetics , in vitro

The host's first line of defense against bloodstream infection with Candida albicans involves the recognition and clearance of the fungus by neutrophils and monocytes/macrophages. The purpose of the present study was to examine changes in the monocytic cell gene-expression profile in response to C. albicans stimulation.

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