Open AccessDisseminated Histoplasmosis in Persons with Interferon- Receptor 1 Deficiency
Author(s) -
Christa S. Zerbe,
Steven M. Holland
Publication year - 2005
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/432120
Subject(s) - histoplasmosis , medicine , histoplasma , immunology , nontuberculous mycobacteria , interferon gamma , histoplasma capsulatum , osteomyelitis , immunity , interferon , receptor , microbiology and biotechnology , mycobacterium , immune system , tuberculosis , pathology , biology
Mutations in the interferon (IFN)-gamma receptor predispose to infection with bacille Calmette-Guérin, nontuberculous mycobacteria, and Salmonella organisms. We identified a patient with recurrent disseminated Histoplasma capsulatum osteomyelitis who had an autosomal dominant form of IFN-gamma receptor 1 deficiency (i.e., a 4-bp deletion at or near base 818). IFN-gamma-mediated immunity is important in the control of histoplasmosis.
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