Paracoccidioides brasiliensis Disseminated Disease in a Patient with Inherited Deficiency in the 1 Subunit of the Interleukin (IL)-12/IL-23 Receptor | Zendy

Dewton de Moraes Vasconcelos | Zendy; Anete Sevciovic Grumach | Zendy; A. Yamaguti | Zendy; Marina Elizabeth Barbosa Andrade | Zendy; Claire Fieschi | Zendy; Ludovic de Beaucoudrey | Zendy; JeanLaurent Casanova | Zendy; A.J.S. Duarte | Zendy

Open Access

Paracoccidioides brasiliensis Disseminated Disease in a Patient with Inherited Deficiency in the 1 Subunit of the Interleukin (IL)-12/IL-23 Receptor

Author(s) -

Dewton de Moraes Vasconcelos,

Anete Sevciovic Grumach,

A. Yamaguti,

Marina Elizabeth Barbosa Andrade,

Claire Fieschi,

Ludovic de Beaucoudrey,

JeanLaurent Casanova,

A.J.S. Duarte

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/432119

Subject(s) - paracoccidioides brasiliensis , paracoccidioidomycosis , immunology , immunodeficiency , medicine , primary immunodeficiency , immunity , tuberculosis , immune system , pathology

Paracoccidioides brasiliensis is a facultative intracellular dimorphic fungus that causes paracoccidioidomycosis (PCM), the most important deep mycosis in Latin America. Only a small percentage of individuals infected by P. brasiliensis develop clinical PCM, possibly in part because of genetically determined interindividual variability of host immunity. However, no primary immunodeficiency has ever been associated with PCM.

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