Open AccessA Randomized, Controlled Study of a Simple, Once-Daily Regimen of Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated, Multidrug-Resistant Falciparum Malaria
Author(s) -
Elizabeth A. Ashley,
Rose McGready,
Robert Hutagalung,
Lucy Phaiphun,
Thra Slight,
Stéphane Proux,
Kyaw L. Thwai,
Marion Barends,
Sornchai Looareesuwan,
Nicholas J. White,
François Nosten
Publication year - 2005
Publication title -
clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/432011
Subject(s) - piperaquine , medicine , regimen , malaria , dihydroartemisinin , plasmodium falciparum , pharmacology , artemisinin , immunology
Dihydroartemisinin-piperaquine (DP) is a fixed-combination antimalarial drug increasingly deployed in Southeast Asia. The current regimen involves 4 doses given over 3 days. Simplification of the dose regimen should facilitate treatment adherence and thereby increase effectiveness.