Bacille Calmette‐Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3‐Dioxygenase in Mice | Zendy

Maïté Moreau | Zendy; Jacques Lestage | Zendy; Danièle Verrier | Zendy; Cécile Mormède | Zendy; Keith W. Kelley | Zendy; Robert Dantzer | Zendy; Nathalie Casta | Zendy

Open Access

Bacille Calmette‐Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3‐Dioxygenase in Mice

Author(s) -

Maïté Moreau,

Jacques Lestage,

Danièle Verrier,

Cécile Mormède,

Keith W. Kelley,

Robert Dantzer,

Nathalie Casta

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/431603

Subject(s) - indoleamine 2,3 dioxygenase , cytokine , kynurenine , interferon gamma , immunology , immune system , tumor necrosis factor alpha , medicine , peripheral , lung , chemistry , tryptophan , biochemistry , amino acid

Activation of the indoleamine 2,3-dioxygenase (IDO) enzyme and the resulting decrease in plasma tryptophan (TRP) levels appears to be a crucial link in the relationship between cytokines and depression. We aimed to develop an experimental model of chronic IDO activation based on bacille Calmette-Guérin (BCG) infection that elicits a robust increase in levels of interferon (IFN)- gamma, a key cytokine in the activation of IDO.

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