Fatal Interaction between Clarithromycin and Colchicine in Patients with Renal Insufficiency: A Retrospective Study | Zendy

Ivan FanNgai Hung | Zendy; A. K. L. Wu | Zendy; Vincent ChiChung Cheng | Zendy; Bone S. F. Tang | Zendy; Kelvin KaiWang To | Zendy; ChungKwong Yeung | Zendy; Patrick C. Y. Woo | Zendy; Susanna K. P. Lau | Zendy; Bmy Cheung | Zendy; KwokYung Yuen | Zendy

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Fatal Interaction between Clarithromycin and Colchicine in Patients with Renal Insufficiency: A Retrospective Study

Author(s) -

Ivan FanNgai Hung,

A. K. L. Wu,

Vincent ChiChung Cheng,

Bone S. F. Tang,

Kelvin KaiWang To,

ChungKwong Yeung,

Patrick C. Y. Woo,

Susanna K. P. Lau,

Bmy Cheung,

KwokYung Yuen

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/431592

Subject(s) - medicine , clarithromycin , concomitant , retrospective cohort study , colchicine , gout , relative risk , gastroenterology , surgery , confidence interval , helicobacter pylori

Clarithromycin is frequently used to treat community-acquired pneumonia in elderly persons. Like erythromycin, it may interact with other drugs by interfering with metabolism by cytochrome P450 enzymes and with the P-glycoprotein transporter system. Colchicine, used for treatment of acute gout and for prophylaxis, may cause bone marrow toxicity. It is metabolized by CYP3A4 and is transported by P-glycoprotein. Initial case reports suggested potentially fatal interactions between clarithromycin and colchicine.

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