Subtype C Is Associated with Increased Vaginal Shedding of HIV‐1 | Zendy

Grace JohnStewart | Zendy; Ruth Nduati | Zendy; Christine Rousseau | Zendy; Dorothy MboriNgacha | Zendy; Barbra A. Richardson | Zendy; Stephanie Rainwater | Zendy; Dana Panteleeff | Zendy; Julie Overbaugh | Zendy

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Subtype C Is Associated with Increased Vaginal Shedding of HIV‐1

Author(s) -

Grace JohnStewart,

Ruth Nduati,

Christine Rousseau,

Dorothy MboriNgacha,

Barbra A. Richardson,

Stephanie Rainwater,

Dana Panteleeff,

Julie Overbaugh

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/431514

Subject(s) - odds ratio , human immunodeficiency virus (hiv) , medicine , cohort , sex organ , lentivirus , viral load , immunology , transmission (telecommunications) , viral shedding , confidence interval , virus , sexual transmission , sida , viral disease , virology , biology , genetics , microbicide , electrical engineering , engineering

The prevalence of human immunodeficiency virus (HIV)-1-infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1-infected vaginal cells than were those infected with subtype A or D (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1.

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