Mice with Disseminated Candidiasis Die of Progressive Sepsis | Zendy

Brad Spellberg | Zendy; Ashraf S. Ibrahim | Zendy; John E. Edwards | Zendy; Scott G. Filler | Zendy

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Mice with Disseminated Candidiasis Die of Progressive Sepsis

Author(s) -

Brad Spellberg,

Ashraf S. Ibrahim,

John E. Edwards,

Scott G. Filler

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430952

Subject(s) - etiology , sepsis , pathogenesis , immunology , medicine , disease , antifungal , biology , microbiology and biotechnology , pathology

Candida species are among the most common etiologies of nosocomial bloodstream infections, causing a mortality of >40%. The murine model of hematogenously disseminated candidiasis is the standard for investigating both the activity of antifungal agents and the pathogenesis of this disease. However, despite decades of use, little is known about the physiological characteristics of the host in this model, and the cause of death remains unclear.

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