Type I Interferon Production Is Profoundly and Transiently Impaired in Primary HIV‐1 Infection | Zendy

Isabelle Kamga | Zendy; Sandrine Kahi | Zendy; Leyla Develioglu | Zendy; Miriam Lichtner | Zendy; Concepción Marañón | Zendy; Christiane Deveau | Zendy; Laurence Meyer | Zendy; Cécile Goujard | Zendy; Pierre Lebon | Zendy; Martine Sinet | Zendy; Anne Hosmalin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Type I Interferon Production Is Profoundly and Transiently Impaired in Primary HIV‐1 Infection

Author(s) -

Isabelle Kamga,

Sandrine Kahi,

Leyla Develioglu,

Miriam Lichtner,

Concepción Marañón,

Christiane Deveau,

Laurence Meyer,

Cécile Goujard,

Pierre Lebon,

Martine Sinet,

Anne Hosmalin

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430931

Subject(s) - peripheral blood mononuclear cell , immunology , viral load , interferon , multicenter aids cohort study , immune system , medicine , viral disease , virology , clinical endpoint , virus , lentivirus , immunopathology , herpes simplex virus , biology , antiretroviral therapy , clinical trial , in vitro , biochemistry

Successful immunological control of human immunodeficiency virus (HIV) infection is achieved only in rare individuals. Plasmacytoid dendritic cells (DCs) are mostly responsible for the production of strong antiviral factors--that is, type I interferons (IFNs)--in response to viruses. Their natural IFN production is impaired in chronic HIV infection, in correlation with viral load and disease progression, but it has not been tested during the critical stage of primary infection, when a balance is set between host immune responses and viral replication.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research