Hepatitis C Virus Core Protein and Hepatitis Activity Are Associated through Transactivation of Interleukin‐8 | Zendy

Yujin Hoshida | Zendy; Naoya Kato | Zendy; Hideo Yoshida | Zendy; Yue Wang | Zendy; Masamichi Tanaka | Zendy; Tadashi Goto | Zendy; Motoyuki Otsuka | Zendy; Hiroyoshi Taniguchi | Zendy; Masaru Moriyama | Zendy; Fumio Imazeki | Zendy; Osamu Yokosuka | Zendy; Takao Kawabe | Zendy; Yasushi Shiratori | Zendy; Masao Omata | Zendy

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Hepatitis C Virus Core Protein and Hepatitis Activity Are Associated through Transactivation of Interleukin‐8

Author(s) -

Yujin Hoshida,

Naoya Kato,

Hideo Yoshida,

Yue Wang,

Masamichi Tanaka,

Tadashi Goto,

Motoyuki Otsuka,

Hiroyoshi Taniguchi,

Masaru Moriyama,

Fumio Imazeki,

Osamu Yokosuka,

Takao Kawabe,

Yasushi Shiratori,

Masao Omata

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430924

Subject(s) - transactivation , hepatitis c virus , interferon , medicine , cytokine , interleukin , immunology , tumor necrosis factor alpha , hepatitis c , hepacivirus , virology , hepatitis , virus , biology , gene expression , biochemistry , gene

We evaluated the association between variations in hepatitis C virus (HCV) core protein and hepatitis severity in patients with chronic HCV infection who achieved remission without viral eradication and had a biochemical response to interferon (IFN) therapy, to evaluate the effect of HCV core sequence in the absence of the influence of host factors. METHODS. Using serum from 10 patients with a biochemical response and 10 patients with no response, we measured serum levels of interleukin (IL)-1 beta , IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IFN- gamma , and tumor necrosis factor- alpha before and after IFN therapy. Expression vectors with the core region were transfected into Huh7 cells, and cytokine induction was evaluated by reporter assay.

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