Evaluation of Serum Sandwich Enzyme-Linked Immunosorbent Assay for Circulating Galactomannan during Caspofungin Therapy: Results from the Caspofungin Invasive Aspergillosis Study | Zendy

Johan Maertens | Zendy; Axel Glasmacher | Zendy; Dominik Selleslag | Zendy; A. Ngai | Zendy; Desmon̄d Ryan | Zendy; M. Layton | Zendy; Amanda Taylor | Zendy; Carole A. Sable | Zendy; Nicholas A. Kartsonis | Zendy

Open Access

Evaluation of Serum Sandwich Enzyme-Linked Immunosorbent Assay for Circulating Galactomannan during Caspofungin Therapy: Results from the Caspofungin Invasive Aspergillosis Study

Author(s) -

Johan Maertens,

Axel Glasmacher,

Dominik Selleslag,

A. Ngai,

Desmon̄d Ryan,

M. Layton,

Amanda Taylor,

Carole A. Sable,

Nicholas A. Kartsonis

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/430826

Subject(s) - galactomannan , caspofungin , medicine , aspergillosis , echinocandin , aspergillus , microbiology and biotechnology , voriconazole , immunology , antifungal , dermatology , biology , fluconazole

There has been minimal clinical experience with the use of the Aspergillus galactomannan enzyme-linked immunosorbent assay (ELISA) for patients receiving echinocandin therapy. We reviewed the experience with the galactomannan ELISA for 17 patients in a study of caspofungin treatment for invasive aspergillosis. The rate of successful outcomes for these patients was similar to that overall for participants in the study. Trends in antigenemia levels correlated with clinical and radiographic findings.

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