Sickle Cell Trait and the Risk ofPlasmodium falciparumMalaria and Other Childhood Diseases | Zendy

Thomas N. Williams | Zendy; Tabitha Mwangi | Zendy; Sammy Wambua | Zendy; Neâl Alexander | Zendy; Moses Kortok | Zendy; Robert W. Snow | Zendy; Kevin Marsh | Zendy

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Sickle Cell Trait and the Risk ofPlasmodium falciparumMalaria and Other Childhood Diseases

Author(s) -

Thomas N. Williams,

Tabitha Mwangi,

Sammy Wambua,

Neâl Alexander,

Moses Kortok,

Robert W. Snow,

Kevin Marsh

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430744

Subject(s) - malaria , sickle cell trait , parasitemia , plasmodium falciparum , medicine , epidemiology , immunology , incidence (geometry) , disease , pediatrics , biology , physics , optics

The gene for sickle hemoglobin (HbS) is a prime example of natural selection. It is generally believed that its current prevalence in many tropical populations reflects selection for the carrier form (sickle cell trait [HbAS]) through a survival advantage against death from malaria. Nevertheless, >50 years after this hypothesis was first proposed, the epidemiological description of the relationships between HbAS, malaria, and other common causes of child mortality remains incomplete.

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