Antiviral Activity of Lamivudine in Salvage Therapy for Multidrug‐Resistant HIV‐1 Infection | Zendy

Thomas Campbell | Zendy; Nancy S. Shulman | Zendy; Steven C. Johnson | Zendy; Andrew Zolopa | Zendy; Russell K. Young | Zendy; Lane R. Bushman | Zendy; Courtney V. Fletcher | Zendy; E. Randall Lanier | Zendy; Thomas C. Merigan | Zendy; Daniel R. Kuritzkes | Zendy

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Antiviral Activity of Lamivudine in Salvage Therapy for Multidrug‐Resistant HIV‐1 Infection

Author(s) -

Thomas Campbell,

Nancy S. Shulman,

Steven C. Johnson,

Andrew Zolopa,

Russell K. Young,

Lane R. Bushman,

Courtney V. Fletcher,

E. Randall Lanier,

Thomas C. Merigan,

Daniel R. Kuritzkes

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/430709

Subject(s) - lamivudine , resistance mutation , virology , medicine , multiple drug resistance , human immunodeficiency virus (hiv) , virus , viral replication , drug resistance , biology , hepatitis b virus , microbiology and biotechnology , reverse transcriptase , polymerase chain reaction , genetics , gene

Maximum suppression of virus replication is often not achievable for persons infected with multidrug-resistant human immunodeficiency virus type 1 (HIV-1). Available data suggest that lamivudine contributes to partial viral suppression, despite the presence of M184V mutations and high-level phenotypic lamivudine resistance.

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