Differential Organization of the Local Immune Response in Patients with Active Cavitary Tuberculosis or with Nonprogressive Tuberculoma | Zendy

Timo Ulrichs | Zendy; George A. Kosmiadi | Zendy; Sabine Jörg | Zendy; Lydia Pradl | Zendy; Marina Titukhina | Zendy; Vladimir Mishenko | Zendy; Nadya Gushina | Zendy; Stefan H. E. Kaufmann | Zendy

Open Access

Differential Organization of the Local Immune Response in Patients with Active Cavitary Tuberculosis or with Nonprogressive Tuberculoma

Author(s) -

Timo Ulrichs,

George A. Kosmiadi,

Sabine Jörg,

Lydia Pradl,

Marina Titukhina,

Vladimir Mishenko,

Nadya Gushina,

Stefan H. E. Kaufmann

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430621

Subject(s) - tuberculoma , tuberculosis , immune system , immunology , mycobacterium tuberculosis , lung , granuloma , biology , differential diagnosis , active tuberculosis , antigen , medicine , pathology

In 90% of all cases, Mycobacterium tuberculosis infection results in latency rather than active disease, with the pathogen being contained within granulomatous lesions at the site of primary infection. Failure of this containment leads to reactivation of postprimary tuberculosis (TB). The regional immune processes that sustain the delicate balance with persistent M. tuberculosis, however, remain unclear.

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