Antibody Avidity Maturation during Severe Acute Respiratory Syndrome–Associated Coronavirus Infection | Zendy

Paul K.S. Chan | Zendy; PakLeong Lim | Zendy; Esther Y.M. Liu | Zendy; Jo L.K. Cheung | Zendy; Danny T. M. Leung | Zendy; Joseph J.�Y. Sung | Zendy

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Antibody Avidity Maturation during Severe Acute Respiratory Syndrome–Associated Coronavirus Infection

Author(s) -

Paul K.S. Chan,

PakLeong Lim,

Esther Y.M. Liu,

Jo L.K. Cheung,

Danny T. M. Leung,

Joseph J.�Y. Sung

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430615

Subject(s) - avidity , antibody , immunology , coronavirus , respiratory system , medicine , immunoglobulin g , virology , biology , covid-19 , disease , infectious disease (medical specialty)

The maturation of virus-specific immunoglobulin G avidity during severe acute respiratory syndrome-associated coronavirus infection was examined. The avidity indices were low (mean +/- SD, 30.8% +/- 11.6%) among serum samples collected < or =50 days after fever onset, intermediate (mean +/- SD, 52.1% +/- 14.1%) among samples collected between days 51 and 90, and high (mean +/- SD, 78.1% +/- 8.0%) among samples collected after day 90. Avidity indices of 40% and 55% could be considered as cutoff values for determination of recent (< or =50 days) and past (>65 days) infection, respectively. Measurement of antibody avidity can be used to differentiate primary infection from reexposure and to assess humoral responses to candidate vaccines.

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