Does Linezolid Cause Lactic Acidosis by Inhibiting Mitochondrial Protein Synthesis? | Zendy

Michio Hirano | Zendy; Lluís Palenzuela | Zendy; Noah M. Hahn | Zendy; R.P. Nelson | Zendy; Janet N. Arno | Zendy; Christian Schobert | Zendy; R. A. Bethel | Zendy; Ł Ostrowski | Zendy; Manjuli R. Sharma | Zendy; P. P. Datta | Zendy; Rajendra K. Agrawal | Zendy; Jennifer E. Schwartz | Zendy

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Does Linezolid Cause Lactic Acidosis by Inhibiting Mitochondrial Protein Synthesis?

Author(s) -

Michio Hirano,

Lluís Palenzuela,

Noah M. Hahn,

R.P. Nelson,

Janet N. Arno,

Christian Schobert,

R. A. Bethel,

Ł Ostrowski,

Manjuli R. Sharma,

P. P. Datta,

Rajendra K. Agrawal,

Jennifer E. Schwartz

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/430441

Subject(s) - linezolid , lactic acidosis , 23s ribosomal rna , medicine , toxicity , ribosomal rna , mitochondrial toxicity , acidosis , pharmacology , microbiology and biotechnology , biochemistry , rna , biology , bacteria , genetics , ribosome , gene , staphylococcus aureus , vancomycin

Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

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