Pilot Study Evaluating C-Reactive Protein Levels in the Assessment of Response to Treatment of Severe Bloodstream Infection | Zendy

Pedro Póvoa | Zendy; Luís Coelho | Zendy; Eduardo Alves de Almeida | Zendy; Antero Fernandes | Zendy; R. Mealha | Zendy; P. Moreira | Zendy; Henrique Augusto Cantareira Sabino | Zendy

Open Access

Pilot Study Evaluating C-Reactive Protein Levels in the Assessment of Response to Treatment of Severe Bloodstream Infection

Author(s) -

Pedro Póvoa,

Luís Coelho,

Eduardo Alves de Almeida,

Antero Fernandes,

R. Mealha,

P. Moreira,

Henrique Augusto Cantareira Sabino

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/430382

Subject(s) - medicine , c reactive protein , antimicrobial , bloodstream infection , immunology , gastroenterology , microbiology and biotechnology , inflammation , biology

We evaluated the usefulness of monitoring daily C-reactive protein (CRP) levels after initiation of antimicrobial therapy in 44 patients with bloodstream infection. The ratio of the CRP level during therapy to the level at the start of antimicrobial therapy (CRP ratio) was measured. A CRP ratio of >0.58 at day 4 of therapy was a marker of poor outcome (sensitivity, 0.89; specificity, 0.69). The recognition of a pattern of CRP-ratio response was useful in the prediction of individual clinical course.

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