HIV-Associated Wasting in the Era of Highly Active Antiretroviral Therapy: A Syndrome of Residual HIV Infection in Monocytes and Macrophages? | Zendy

Cecilia Shikuma | Zendy; Victor Valcour | Zendy; Silvia RattoKim | Zendy; Andrew E. Williams | Zendy; Scott A. Souza | Zendy; Mariana Gerschenson | Zendy; Lisa Day | Zendy; J. H. Kim | Zendy; Bruce Shiramizu | Zendy

Open Access

HIV-Associated Wasting in the Era of Highly Active Antiretroviral Therapy: A Syndrome of Residual HIV Infection in Monocytes and Macrophages?

Author(s) -

Cecilia Shikuma,

Victor Valcour,

Silvia RattoKim,

Andrew E. Williams,

Scott A. Souza,

Mariana Gerschenson,

Lisa Day,

J. H. Kim,

Bruce Shiramizu

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/430376

Subject(s) - wasting , medicine , peripheral blood mononuclear cell , immunology , antiretroviral therapy , viral load , wasting syndrome , virology , human immunodeficiency virus (hiv) , sida , viral disease , immunopathology , virus , in vitro , biology , biochemistry

Human immunodeficiency virus (HIV) infection in peripheral blood mononuclear cells (PBMCs) might be influencing the development of wasting in the era of potent antiretroviral therapy. In a retrospective study of 57 subjects, HIV proviral DNA levels in PBMCs were higher in subjects whose body weight decreased by >5% one year after initiation of highly active antiretroviral therapy, compared with subjects whose body weight was stable or increased (median HIV proviral DNA load, 8.9 vs. 0.9 copies/10(6) PBMCs; P = .006).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research