Antigenic Cross‐Reactivity between Severe Acute Respiratory Syndrome–Associated Coronavirus and Human Coronaviruses 229E and OC43 | Zendy

ChiMing Che | Zendy; Liwen Qiu | Zendy; Zhiyong Liao | Zendy; Yadi Wang | Zendy; Kun Wen | Zendy; Yuxian Pan | Zendy; Wei Hao | Zendy; Yabo Mei | Zendy; Vincent ChiChung Cheng | Zendy; KwokYung Yuen | Zendy

Open Access

Antigenic Cross‐Reactivity between Severe Acute Respiratory Syndrome–Associated Coronavirus and Human Coronaviruses 229E and OC43

Author(s) -

ChiMing Che,

Liwen Qiu,

Zhiyong Liao,

Yadi Wang,

Kun Wen,

Yuxian Pan,

Wei Hao,

Yabo Mei,

Vincent ChiChung Cheng,

KwokYung Yuen

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430355

Subject(s) - cross reactivity , antigen , virology , coronavirus , antibody , immunofluorescence , western blot , titer , respiratory system , biology , immunology , covid-19 , medicine , cross reactions , pathology , gene , infectious disease (medical specialty) , disease , biochemistry , anatomy

Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a > or =4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.

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