No Serological Evidence of Association between Prostate Cancer and Infection with Herpes Simplex Virus Type 2 or Human Herpesvirus Type 8: A Nested Case‐Control Study | Zendy

Zoltan Korodi | Zendy; Xiaohong Wang | Zendy; Rosamaria Tedeschi | Zendy; Paul Knekt | Zendy; Joakim Dillner | Zendy

Open Access

No Serological Evidence of Association between Prostate Cancer and Infection with Herpes Simplex Virus Type 2 or Human Herpesvirus Type 8: A Nested Case‐Control Study

Author(s) -

Zoltan Korodi,

Xiaohong Wang,

Rosamaria Tedeschi,

Paul Knekt,

Joakim Dillner

Publication year - 2005

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/430354

Subject(s) - odds ratio , medicine , herpes simplex virus , prostate cancer , immunology , nested case control study , case control study , serology , cancer , oncology , antibody , virus

Sexual history has consistently been found to be a risk factor for the development of prostate cancer. An association between prostate cancer and herpes simplex virus type 2 (HSV-2) or Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 (HHV-8) infections has also been reported. Linkage of data on a cohort of 20,243 healthy Finnish men identified 165 cases of prostate cancer that were diagnosed up to 24 years after donation of a serum sample. Two control subjects were matched by age, sex, and municipality of residence to each case patient. Serum levels of immunoglobulin G against HSV-2 and HHV-8 were determined. Neither HSV-2 infection (odds ratio [OR], 0.93 [95% confidence interval {CI}, 0.44-1.96]) nor HHV-8 infection (OR, 0.74 [95% CI, 0.19-2.88]) was associated with prostate cancer.

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