Posaconazole as Salvage Therapy in Patients with Chronic Granulomatous Disease and Invasive Filamentous Fungal Infection | Zendy

Brahm H. Segal | Zendy; Lisa Barnhart | Zendy; Virgil L. Anderson | Zendy; Thomas J. Walsh | Zendy; Harry L. Malech | Zendy; Steven M. Holland | Zendy

Open Access

Posaconazole as Salvage Therapy in Patients with Chronic Granulomatous Disease and Invasive Filamentous Fungal Infection

Author(s) -

Brahm H. Segal,

Lisa Barnhart,

Virgil L. Anderson,

Thomas J. Walsh,

Harry L. Malech,

Steven M. Holland

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/430068

Subject(s) - posaconazole , medicine , chronic granulomatous disease , salvage therapy , antifungal , phaeohyphomycosis , immunology , dermatology , voriconazole , surgery , chemotherapy

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.

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