Successful Treatment ofFusarium Keratitis with Cornea Transplantation and Topical and Systemic Voriconazole | Zendy

Rocus R. Klont | Zendy; C.A. Eggink | Zendy; Antonius J. M. M. Rijs | Zendy; Pieter Wesseling | Zendy; Paul E. Verweij | Zendy

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Successful Treatment ofFusarium Keratitis with Cornea Transplantation and Topical and Systemic Voriconazole

Author(s) -

Rocus R. Klont,

C.A. Eggink,

Antonius J. M. M. Rijs,

Pieter Wesseling,

Paul E. Verweij

Publication year - 2005

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/430062

Subject(s) - voriconazole , medicine , itraconazole , cornea , keratitis , fungal keratitis , amphotericin b , dermatology , corneal transplantation , drug , transplantation , surgery , antifungal , ophthalmology , pharmacology

A case of invasive Fusarium keratitis in a previously healthy male patient was treated successfully with cornea transplantation and systemic and topical voriconazole after treatment failure with topical amphotericin B and systemic itraconazole. Topical voriconazole was well tolerated, and, in conjunction with the oral administration, it resulted in a high level of the drug in the anterior chamber of the eye (which was 160% of the plasma drug level).

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